PROCÉDÉ D'AMÉLIORATION DE L'ADSORPTION DE CONJUGUÉS POLYSACCHARIDE-PROTÉINE ET FORMULATION DE VACCIN MULTIVALENT OBTENUE PAR CELUI-CI

• 收藏
• 分享

专利权人:

Serum Institute Of India Private Limited

发明人:

申请号：

EP16806975.5

公开号：

EP3302542A4

申请日:

2016.06.03

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable formulations show optimal percent adsorption for each conjugate wherein, aggregation can be prevented by employing i) Individual or separate adsorption for conjugates that otherwise show lower percent adsorption by combined adsorption ii) Histidine-Succinic acid buffer system along with shift in pH from neutral pH to acidic pH iii) a polysaccharide to protein ratio between 0.5 to about 1.4 iv) a six-bladed Rushton type turbine impeller in formulation vessels.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/