Carlo Ballatore,Kurt R. Brunden,Adam T. Hoye,Virginia M.Y. Lee,Amos B. Smith,John Q. Trojanowski
申请号：
US14429101
公开号：
US20150224105A1
申请日:
2013.09.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment of neurodegenerative disorders, in particular, tauopathies, such as for example, Alzheimers disease, frontotemporal lobar degeneration, Picks disease, progressive supranuclear palsy (PSP), and corticobasal degeneration. In addition, the compounds of the invention may be useful for other diseases where tau pathology is a comorbidity or where microtubule function is compromised, for example, schizophrenia, Parkinsons disease (PD), PD with dementia, Lewy body disease with dementia, and amyotrophic lateral sclerosis.
