PROBLEM TO BE SOLVED: To provide a conjugate of a peptide having activity against a glucagon receptor, a GLP-1 (Glucagon-like peptide-1) receptor, and a GIP (Glucose-dependent insuliontropic polypeptide) receptor. The present invention relates to a sustained conjugate of a triple activator having activity on all of glucagon, GLP-1 and the GIP receptor and its use. [Selection diagram] Fig. 1【課題】グルカゴン受容体、ＧＬＰ－１（Glucagon-like peptide-1）受容体、及びＧＩＰ（Glucose-dependent insuliontropic polypeptide）受容体に対して活性を有する、ペプチドの結合体を提供すること。【解決手段】本発明は、グルカゴン、ＧＬＰ－１及びＧＩＰ受容体のすべてに活性を有する三重活性体の持続型結合体及びその用途に関する。【選択図】図１
