A discriminating connector system for medical use. The connector system includes a male connector and a female connector. A standoff of the male connector forms a sealed, fluid connection with a receptacle of the female connector for fluid flow between conduits connected to the male and female connectors. The construction of the connector system prevents connection of either the male or female connector to other non-conforming connectors or syringes commonly found in medical environments, such as male and female luer-lock connectors and syringes.