EDWARDS, CHRISTINE,KULAGOWSKI, JANUSZ,FINCH, HARRY
申请号：
CA2792725
公开号：
CA2792725C
申请日:
2011.03.10
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to compounds of formula (I)(see formula I)wherein A is C-R1； R1 and R2 are hydrogen； R4 is hydrogen； R5 is hydrogen；R3 is trifluoromethyl, 3-chloro or 3-bromo； R6 is -CO2R11； -X1X2- is -NR19-CO-；R11 represents a radical of formula -[Alk1]p-[Q]r-[Alk2]q-Z wherein p, q areindependently 0 or 1, t is 0； Alk1 and Alk2 each independently represent aC1-C6 alkylene radical； Z is (i) -N(R A)(R B) wherein R A and R B areindependentlyhydrogen, or a C1-C6-alkyl； or (ii)-N+(R A)(R B)(R C) wherein R A, R B and R Careindependently a C1-C6-alkyl； R19 is hydrogen or (C1-C6)alkyl. These compoundsareinhibitors of neutrophil elastase. The compounds of the invention andpharmaceutical compositions prepared therefrom are useful in the treatment ofdiseases and conditions in which human neutrophil elastase plays a part.
