Novel α-1 antitrypsin mutant, production method and use thereof

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专利权人:

アルテオゼン，;インク;アルテオゼン, インク

发明人:

パク、ソン チェ,チョン、ヘ－シン,イ、サン ミ,キム、チ ソン,チョン、ヘ-シン

申请号：

JP2014530581

公开号：

JP6001074B2

申请日:

2012.08.13

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

A novel alpha-1 antitrypsin variant, a method of preparing the same, and use thereof are provided. The alpha-1 antitrypsin variant has excellent stability in the body and maintains an inhibitory effect on elastase activities because the blood half-life (t 1/2 ) and the area under blood drug concentration vs. time curve (AUC) are remarkably increased by adding an N-glycosylation site in animal cells through amino acid mutation between 1 st and 25 th positions of the N-terminus of alpha-1 antitrypsin. Therefore, the alpha-1 antitrypsin variant can be useful in preventing or treating alpha-1 antitrypsin deficiency.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/