A computer-based system for creating and using intelligent databases for assisting in intima-media thickness (IMT) measurements. Various embodiments utilize clinical data (images) to design intelligent clinical data sets, including geometric markers like blood vessel centerline, which can then be used with conventional image processing to compute the intima-media thickness of the carotid walls. The intelligent clinical image data utilizes the demographics (ethnity/race, gender and age) to classify the data. Finally, the intelligent database is used to collect intelligent parameters which are then applied to the incoming patients to estimate their intima-media thickness.
