Humanised antibodies to toll-like receptor 2 and uses thereof

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专利权人:

OPSONA THERAPEUTICS LIMITED

发明人:

DELLACASAGRANDE JEROME

申请号：

NZ61544110

公开号：

NZ615441A

申请日:

2010.07.06

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

Disclosed is an isolated monoclonal antibody, or antigen binding portion thereof, which binds an epitope on human Toll-like Receptor 2 with a KD of 3x10-8 M or less and which mediates TLR2 antagonism independent of binding of the antibody or the antigen binding portion thereof to CD32 (Fc gamma receptor II), wherein the epitope (SEQ ID NO: 13 KEESSNQASLSCDRNGICKGS and SEQ ID NO: 14 CSCEFLSFTQEQQ) is recognised by a reference antibody and wherein that reference antibody is comprised of SEQ ID NO:4 or 5 and SEQ ID NO: 1 or 2.

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