Nucleic acids containing a synthetic codon-optimized Sin Nombre virus full-length M gene

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专利权人:

Jay Hooper

发明人:

Jay Hooper

申请号：

US13982606

公开号：

US09315826B2

申请日:

2011.01.31

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.

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