George D. Maynard;Andrew Thurkauf;Bertrand L. Chenard;George P. Luke;Suoming Zhang;He Zhao;Bingsong Han;Scott Mitchell;Linghong Xie;Yang Gao;LuYan Zhang;Xiao Shu He
发明人:
George P. Luke,George D. Maynard,Scott Mitchell,Andrew Thurkauf,Linghong Xie,LuYan Zhang,Suoming Zhang,He Zhao,Bertrand L. Chenard,Yang Gao,Bingsong Han,Xiao Shu He
申请号：
US11680865
公开号：
US08119665B2
申请日:
2007.03.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides packaged pharmaceutical preparations of Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formulawhere the variables are defined herein.Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
