The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compound of the present invention is useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.本發明提供一種具有BACE1抑制活性的式I化合物、 其製造、含有其之醫藥組合物及其作為治療活性物質之用途。本發明之活性化合物適用於例如阿茲海默氏症(Alzheimer's disease)之治療性及/或預防性治療。
