Disclosed is a packaged enema for the treatment of inflammatory bowel disease and related conditions, comprising: an effective and stable dosage suspension of substantially pure 5-ASA contained within a substantially oxygen-free liquid carrier medium, said liquid carrier medium having a material avoidance of antioxidants for said 5-ASA at least one application bottle containing said effective dosage suspension a sealed, substantially oxygen-free barrier package containing therein said at least one application bottle containing said effective dosage suspension, and an oxygen scavenger and said barrier package sufficient to prevent migration of oxygen thereinto and to said dosage suspension upon prolonged storage.