Provided herein is a method of reducing postprandial concentrations of glucose in a subject s blood comprising administering to the subject prior to or during a meal an effective amount of a combination of a marine peptide and a fish nucleotide sufficient to reduce the glucose concentration in the subject s blood. Further provided herein is a method of reducing postprandial concentration of ghrelin in a subject s blood comprising administering to the subject prior to or during a meal an effective amount of a combination of a marine peptide and a fish nucleotide sufficient to increase the blood component wherein the combination is administered to the subject.