A device for painless and low invasive parenteral administration of pharmaceutical preparations and blood sampling, including a cuff similar to the cuff for measuring the arterial tension, wherein a fastening frame is arranged for receiving a slide disk comprising a front half-disk and a rear half-disk with a bore for receiving a cartridge with a needle holder, an anesthetic flask and a scanning device, said front half-disk and rear half-disk being movably spaced apart at a distance. When the half-disks are pressed together, the scanning device detects a vein, a sound or light signal is generated, and the half-disks are held in the respective positions. Anesthetic is sprayed by the medical staff or the patient himself and after a time required for anesthetic to act, the needle is inserted into the circulatory bed by pressing the holder cover so that the cover is turned back and via the cone-shaped sealed plug under the pad, the syringe nozzle, the cannula of a blood transfusion system or the cannula of a blood sampling vacuum tube is inserted. The device enables a painless and low-invasive procedure, allows the patient to use the same without the medical staffs aid and is inexpensive.