In one embodiment, a ligator adapted for use with an endoscope includes a ligator body adapted to mount to a body of the endoscope, a barrel adapted to mount to a distal tip of a shaft of the endoscope, the barrel supporting multiple elastic bands that can be sequentially deployed onto internal tissue, and an activation mechanism supported by the ligator body, the activation mechanism including a rotatable activation knob, a rotatable cord winding ring, an activation cord, and a stop element that limits rotation of the activation knob to rotation between a start position and an end position beyond which no further rotation is possible.
