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Derivative of N - tienilbenzamida replaced with aminoalquilo
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
ARP120104035
公开号:
AR088563A1
申请日:
2012.10.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
A compound (npt-iib) with phosphate intestinal transmitter inhibitory activity, which can be used as an active component of a preparation for the treatment and / or prevention of hyperphosphate. 2. Compounds with active ingredients that inhibit activities as described in article 2b of the NPT and can be used as a preparation for the treatment and / or prevention of hyperphosphates. Therefore, they have manufactured an n-tienilbenzamida derivative, which is substituted by aminobenzene with the effect of npt-iib inhibitor.And that's how it is now. The n-tienilbenzamida derivatives substituted with carbamates have the inhibitory activity of npt-iib, which can be used as a preventive or therapeutic agent for hyperphosphates. 1. Claim 1: a formula compound (1) or one of its salts, X1 represents ch832220 u; K represents 1, 2 or 3; R 3 represents h or lower tar; x2 represents ch or N; 1 represents lower tar; R 1 represents h or lower tar; X3 represents ch or N; L 2 represents lower tar; R83099 is the tar of H or below; r8310 is h, the lower tar, the lower tar replaced by - or830404 of 1-2;-C (o) - lower asphalt, - S (o) - 8344; - lower asphalt, - lower asphalt, - n (lower asphalt) 832222;-R83044; r83044 heterocycle; r83044-phenyl, o-r83044; 83044-cyclopentyl, in which case one or two lower tar or C (or) - lower tar can be used to replace phenyl and cyclopentyl, y-r83044; and - r83044;R8304;; r830404 represents lower binding or tar; r830404 represents h or lower tar; m represents 0, 1 or 2; L3 represents lower tar; n represents 0 or 1; r8308 represents h, lower tar coo-r83044;-Low pressure tar - or83044;-Low pressure tar-nhr83044,-Low pressure tar-n (low pressure tar) 832222;O cycloquilo; L83088 represents an alliance, o-nr.83044 -;This is equivalent to - r83044; 83044 - monocyclic heterocycle - r83044; 83044;-R8304; - 830404-phenyl-r8304; - 830404;-Low pressure tar - No. 830404 - low pressure tar2. Lower or lower pitch or lower pitch can be replaced by a hydroxyl group; R2
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