Antibody, recombinant vaccine and pharmaceutical composition for detection and treatment of malaria for Plasmodium infection P. falciparum antigen are provided. A method of synchronizing Plasmodium infection in tissue culture is also provided, comprising administering to the cultures a pharmaceutical composition comprising at least one antibody, removal of which releases the nuclear division arrest, allowing the population to develop through the subsequent stages synchronously. A diagnostic kit is also provided for in vitro detection of Plasmodium infections.