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Modified Bacteria and their Uses thereof for the Treatment of Cancer or Tumor
专利权人:
THE UNIVERSITY OF HONG KONG
发明人:
Jian-dong HUANG,Bin YU,Mei YANG,Lei SHI
申请号:
US13871716
公开号:
US20130295054A1
申请日:
2013.04.26
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Described herein is a method of treatment of cancer or tumor using a modified bacteria or composition comprising the modified bacteria. In certain embodiments, the method is in combination with other treatment. In certain embodiments, the treatment is chemotherapy, radiation therapy, gene therapy, surgery or a combination thereof. The method makes modified facultative anaerobic bacteria into a conditional obligate anaerobe. The modified bacteria are strictly hypoxia regulated and comprise an essential gene expressing cassette. The vectors of this method comprise the essential gene expressing cassette. Also described herein are therapeutic and prophylactic compositions comprising the modified bacteria. The therapeutic and prophylactic compositions contain a purified form of the modified bacteria, while in certain embodiments, they do not contain other strain of microorganisms. The modified bacteria grow within the solid tumor/cancer, retarding its growth and are rapidly eliminated from normal tissues. The solid tumor/cancer includes breast cancer, liver cancer or neuroblastoma.
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中国工程科技知识中心
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