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COMPOSITIONS AND METHODS FOR INCREASING MESENCHYMAL STROMAL CELL MIGRATION TO TUMORS
专利权人:
发明人:
Guillermo Daniel MAZZOLINI,Mariana Gabriela GARCIA,Juan BAYO
申请号:
US14916963
公开号:
US20160220612A1
申请日:
2014.09.05
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present application is directed to compositions and methods for treating a subject with cancer and/or increasing migration of a mesenchymal stromal cells (MSCs) stimulated with a recombinant autocrine motility factor (rAMF) to a tumor or a tumor cell, e.g. hepatocellular carcinoma (HCC). In addition, methods for increasing adhesion of MSCs to endothelial cells with rAMF are disclosed. In some embodiments, the MSCs comprise a therapeutic agent, e.g., an anti-tumor agent.
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