GUND VITTHAL GENBHAU,SHINGOTE SANTOSH SHIVAJI,KULKARNI PRASAD RAMAKANT,ZAWARE NAVNATH RAMDAS
申请号：
IN3279/MUM/2012
公开号：
IN2012MU03279A
申请日:
2012.11.12
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to a novel process for the preparation of Cytidine 5-diphosphate choline and its monosodium salt without using ion exchange resin for purification. More particularly, the present invention relates to a novel process for the preparation of monosodium salt of CDP-choline, avoiding use of ion exchange resin for purification, comprising steps of reacting cytidine 5- monophosphate with morpholine in presence of dicyclohexylcarbodiimide in methanol to obtain cytidine 5-monophosphate morpholidate condensing cytidine 5-monophosphate morpholidate with phosphorylcholine chloride calcium salt in methanol in presence of hydrochloric acid recovering methanol to obtain thick semisolid mass of CDP-choline dissolving or suspending thick semisolid mass in water, optionally followed by filtration removing calcium from the solution in form of calcium salt, subjecting clear solution to nanofilteration and charcoalization concentrating the solution optionally converting CDP-choline in concentrated solution into its monosodium salt and isolating thus formed monosodium salt of CDP-choline by adding organic solvent selected from a group consisting of alcohol, ketone or mixture thereof.
