ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.;THE GOVERNING COUNCEL OF THE UNIVERSITY OF TORONTO;U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND
发明人:
Jonathan R. Lai,Jayne F. Koellhoffer,Julia Frei,Kartik Chandran,Sachdev Sidhu,Gang Chen,John M. Dye,Samantha Zak
申请号：
US15327857
公开号：
US10435461B2
申请日:
2015.08.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.
