A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-ben zyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with 4-[(S)-2-azetidin-1-yl-1-(4-chloro-3-trifluoromethyl-phenyl)-et hylamino]-quinazoline-8-carboxylic acid amide.Una composición farmacéutica de 3-(1-{3-[5-(1-metil-piperidin-4-il metoxi)-pirimidin-2-il]-bencil}-6-oxo-1,6-dihidro-piridazin-3-il) -benzonitrilo o una sal y/o solvato farmacéuticamente aceptable del mismo en combinación con amida del ácido 4-[(S)-2-azetidin-1-i l-1-(4-cloro-3-trifluorometil-fenil)-etilamino]-quinazolin-8-carb oxílico.