SANJAY MUDUR,NICOLE MILLER DAMOUR,LISA DUONG,KRISTOS ADRIAN MOSHOS,VALDAS JURKAUSKAS,JOSEPH TERRACCIANO,JASON WOERTINK,ASLI OVAT,YOU SEOK HWANG
申请号：
NZ63176114
公开号：
NZ631761A
申请日:
2014.09.12
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are solid forms of ceftolozane sulfate. Ceftolozane is also known as ((6R,7R)-3-[(5-amino-4-{ [(2-aminoethyl)carbamoyl]amino} -1-methyl-1H-pyrazol-2-ium-2-yl)methyl]-7-({ (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl} amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate). Form 1 has diffractions at angles (2 theta ±0.2) of 12.4, 16.4, 22.6, 25.1, and 28.0. In a preferred embodiment the solid form is Form 2 which has diffractions at angles (2 theta ±0.2) of 4.4, 8.8, 11.0, 14.9, and 17.7. Additionally provided are pharmaceutical compositions comprising the solid forms and involving the process of lyophilising the solid forms. The pharmaceutical compositions can additionally contain tazobactam. Ceftolozane is an antibacterial agent.
