Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating α7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.本發明提供經取代之啶化合物、包含此等化合物之醫藥組成物及使用此等化合物以調節α7菸鹼乙醯膽鹼受體且治療神經失調症之方法。