ENHANCEMENT OF TRANSPORT OF THERAPEUTIC MOLECULES ACROSS THE BLOOD BRAIN BARRIER

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专利权人:

发明人:

FARRINGTON GRAHAM K,SISK WILLIAM

申请号：

IN5451/DELNP/2014

公开号：

IN2014DN05451A

申请日:

2014.07.02

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

The invention is based at least in part on the finding that a dimeric version of a BBB transmigrating antibody (e.g. theTMEM30A (CDC 50A) binding antibody FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 V The invention provides inter alia molecules that increase transport of pharmacologically active agents across the blood brain barrier methods for increasing transport across the blood brain barrier and methods of treatment of disorders or diseases having a neurological component.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/