PROBLEM TO BE SOLVED: To provide botulinum toxin oral formulations which exhibit gastric retention by mucoadhesion, flotation, sedimentation, expansion, or drug-induced delay of gastric emptying, to reduce gastrointestinal motility.SOLUTION: An oral composition comprises: a botulinum toxin flour, sugar and gelatin and a carrier such as a polymer comprising polylactides, polyglycolides and polyanhydrides. The oral composition is for treatment of abnormal bowel function, abdominal distention, constipation, Crohn disease, diarrhea, fat malabsorption, gastrointestinal reflux, inflammatory disease, peptic ulcers, hemorrhoids, hernia, obesity, and the like.COPYRIGHT: (C)2014,JPO&INPIT【課題】胃腸運動性を低下させるための、粘膜付着、浮遊、沈降、拡張、または薬剤による胃内容物排出遅延により胃内滞留を示すボツリヌス毒素経口製剤の提供。【解決手段】ボツリヌス毒素および穀粉、糖およびゼラチンやポリラクチド、ポリグリコリドやポリ無水物から成るポリマー等の担体を含有する、腸機能異常、腹部膨満、便秘、クローン病、下痢、脂肪吸収不良、胃腸逆流、炎症性疾患、消化性潰瘍、痔、ヘルニアおよび肥満等を処置する経口組成物。【選択図】なし
