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COMPOSITIONS OF 2-IMINOBIOTINE AND THEIR USE
专利权人:
НЕЙРОФИКСИА Б.В. (NL)
发明人:
ЛЁФКЕНС Пауль Виллем Тересиа Йосеф (NL)
申请号:
RU2013152229/15
公开号:
RU2013152229A
申请日:
2011.05.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. An aqueous soluble composition of 2-iminobiotin having a pH of from about 3 to about 7 and containing about 1 mg / ml or more of 2-iminobiotin and from about 2.5 to about 40% substituted beta-cyclodextrin. A composition according to claim 1, having a pH of from about 4 to about 7 and containing about 2 mg / ml or more of 2-iminobiotin and from about 2.5 to about 20% of the substituted beta-cyclodextrin. A composition according to claim 1, having a pH from about 4 to about 6.5 and containing from about 0.5 to 3.5 mg / ml or more of 2-iminobiotin and from about 5 to about 40, preferably from about 5 to about 10 % substituted beta-cyclodextrin. 4. A composition according to claim 1, having a pH of about 4 and containing about 3.5 mg / ml or more of 2-iminobiotin and from about 2.5 to about 40%, preferably from about 2.5 to about 10%, of beta-cyclodextrin sulfobutyl ether (SBE-CD) .5. A composition according to claim 1, having a pH of from about 4 to about 5 and containing from about 0.5 to about 5 mg / ml, preferably from about 4 to about 5 mg / ml of 2-iminobiotin and from about 2.5 to about 5 % SBE-CD. 6. The composition according to any one of paragraphs. 1-5, additionally containing citric acid, its deprotonated form or a mixture thereof. 7. An aqueous soluble composition of 2-iminobiotin having a pH of from about 3 to about 7 and containing about 0.75 mg / ml or more of 2-iminobiotin and citric acid, its deprotonated form, or a mixture thereof, preferably in an amount of at least 20 mM. The composition according to any one of paragraphs. 1, 5 or 7 for use in the treatment of perinatal asphyxia in a newborn. 9. The composition according to claim 6 for use in the treatment of perinatal asphyxia in a newborn. The composition according to claim 8, characterized in that the composition is administered to the newborn. The composition according to p. 8, excellent1. Водный растворимый состав 2-иминобиотина, имеющий pH от примерно 3 до примерно 7 и содержащий примерно 1
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