Processes for the production of chemically-modified heparins

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专利权人:

DILAFOR AB

发明人:

Per-Olov Eriksson,Erik Yngve Holmer

申请号：

US14898862

公开号：

US10023659B2

申请日:

2014.06.19

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to a process for the production of heparin derivatives having an average molecular weight of from about 4.6 to about 6.9 kDa and an anti-factor Xa activity of less than about 10 IU/mg, comprising the steps of oxidation of unfractionated heparin, depolymerisation and reduction of resulting terminal groups.

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