methods for determining the suitability of a neo-epitope, for determining the suitability of a combination for providing a vaccine, for providing a recombinant immune cell, for providing an immune response, and for treating a mammal with a disease, vaccine and immune cell recombinant
The present invention relates to methods for determining whether neo-epitopes that are only expressed on or on diseased cells are suitable disease-specific targets, so that the diseased cell is less likely to escape immune surveillance, and the use of neo-epitopes. -epitopes in providing an immune response against diseased cells expressing the neo-epitopes.a presente invenção refere-se a métodos para determinar se neo-epítopos que são apenas expressos em ou sobre células doentes são adequados alvos específicos de doença, de forma que a célula doente é menos provável de escapar da vigilância imune, e o uso dos neo-epítopos em proporcionar uma resposta imune contra células doentes que expressa os neo-epítopos.
