BUTLER, DAVID,IWAMOTO, NAOKI,MEENA,SVRZIKAPA, NENAD,VERDINE, GREGORY L.,ZLATEV, IVAN
申请号：
CA2878945
公开号：
CA2878945A1
申请日:
2013.07.12
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonulcleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.
