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MANUFACTURING MULTI-DOSE INJECTION READY DENDRITIC CELL VACCINES
专利权人:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人:
CZERNIECKI, BRIAN J.,KOSKI, GARY K.
申请号:
CA2986687
公开号:
CA2986687A1
申请日:
2016.03.05
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
The present embodiments relate to an FDA- approved injectable multi-dose antigen pulsed dendritic cell (DC) vaccine. In one embodiment, the activated antigen-loaded DC vaccine comprises an initial immunizing dose and multiple "booster"doses. Also provided is a method of blocking both HER-2 and HER-3 as a treatment in causing permanent tumor senescence in HER-2 expressing breast cancers. Also provided is combination anti-estrogen therapy and anti-HER2 dendritic call vaccination for ERpos/HER2pos DCIS breast cancer patients.
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