MANUFACTURING MULTI-DOSE INJECTION READY DENDRITIC CELL VACCINES

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专利权人:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人:

CZERNIECKI, BRIAN J.,KOSKI, GARY K.

申请号：

CA2986687

公开号：

CA2986687A1

申请日:

2016.03.05

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present embodiments relate to an FDA- approved injectable multi-dose antigen pulsed dendritic cell (DC) vaccine. In one embodiment, the activated antigen-loaded DC vaccine comprises an initial immunizing dose and multiple "booster"doses. Also provided is a method of blocking both HER-2 and HER-3 as a treatment in causing permanent tumor senescence in HER-2 expressing breast cancers. Also provided is combination anti-estrogen therapy and anti-HER2 dendritic call vaccination for ERpos/HER2pos DCIS breast cancer patients.

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