Marc Besman,Stewart Chipman,David Leung,Jack Singer
申请号：
US12251324
公开号：
US08129348B2
申请日:
2008.10.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
