The device of the invention may include an interlaced portion (1) and internal inserts (17) that exit the interlaced portion, form a loop, e.g., an external member, and optionally re-enter the interlaced portion. The interlace portion may filter and/or deflect emboli or other large objects from entering protected secondary vessels, while the external member may facilitate device placement within the primary vessel. The device may further be compatible with common delivery methods used in interventional cardiology (e.g., TAVI procedures). The device may be integrated into a delivery system. In other embodiments, the device may be detachable from the delivery system. Upon deployment, the device may be positioned so as to contact the orifice of one or more secondary blood vessels to, e.g., the aortic arch. In still other embodiments, the filaments may be arranged so that the edge of the device is relatively flexible and may serve as a gasket for improved device performance within a primary vessel.
