There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.本發明揭示形成化學鎖固之雙特異性或異源二聚體抗體之方法,該等抗體較佳為IgG種類,具有高特異性及高均質性。更具體而言,本發明揭示具有以生物正交點擊化學連接至一起之鏈接區之化學鎖固之雙特異性IgG種類抗體。