John Gordon Allen;Karin Briner;Anne Marie Camp;Manuel Javier Cases-Thomas;Richard Charles Hoying;Maria Angeles Martinez-Grau;Michael Philip Mazanetz;Natalia Pokrovskaia;Richard Edmund Rathmell;Roger R
发明人:
John Gordon Allen,Karin Briner,Anne Marie Camp,Manuel Javier Cases-Thomas,Richard Charles Hoying,Maria Angeles Martinez-Grau,Michael Philip Mazanetz,Natalia Pokrovskaia,Richard Edmund Rathmell,Roger R
申请号：
US11995344
公开号：
US08420631B2
申请日:
2006.09.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where R6 is —C≡C—R10, —CH═CR11R11′, or —(C0-C8)alkyl-Ar2 optionally substituted on the alkyl moiety with 1 to 6 fluoro substituents and other substituents are as defined in the specification.
