Бухтояров Олег Викторович (RU),Самарин Денис Михайлович (RU)
申请号：
RU2015101109
公开号：
RU2015101109A
申请日:
2015.01.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method for predicting recurrence of malignant tumor process in cancer patients, characterized in that based on the delayed type hypersensitivity and is administered intradermally in a patient tumor associated antigens (TAA) followed by measurement of skin hyperemia zone size in millimeters, after a predetermined monitoring time after administration OAA , the lack of response of the skin redness indicate a pronounced inhibition of specific anti-tumor activity of the immune system onco ol and correspondingly high likelihood of recurrence of a malignant tumor disease, the size of the skin flushing less established control value indicates inhibition of specific anti-tumor activity of the immune system of cancer patients and, accordingly, the average probability of recurrence of cancer diseases, the size of the skin hyperemia above the set reference value represents active state of a specific antitumor immunity and, consequently, a low probability of recurrence onkozabolevaniya.2. The method of claim. 1, characterized in that the TAA lysed using human melanoma cell line BRO tysyach 25 in an amount of lysed cells in 0.05 ml of physiological saline, allow for reaction results after 12 hours after administration antigenov.3. The method of claim. 1, characterized in that as used TAA lysed melanoma cell lines of other cheloveka.4. A method according to claim 1, characterized in that the OAA is used as the lysed cells of other human tumor lines, such as:. Line human colon cancer cells, renal cancer,1. Способ прогнозирования рецидива злокачественного опухолевого процесса у онкобольных, отличающийся тем, что основан на реакции гиперчувствительности замедленного типа и заключается во внутрикожном введении пациенту опухолеассоциированных антигенов (ОАА) с последующим измерением размеров зоны гиперемии кожи в миллиметрах по истечении заранее определенного контрольного времени после введения ОАА, отсутствие реакции гиперемии кожи указывает на выраженное угнетение специфической
