Disclosed is a minimally invasive surgical instrument with a driving single-side plate arrangement. The minimally invasive surgical instrument comprises a proximal driving part (1), a housing (2), a rod (5), a deformation section (6) and a distal effector (7), the proximal driving part (1) comprising an integral driving and rotating mechanism, a deformation section deflection driving mechanism and a distal effector opening and closing driving mechanism (10), wherein the integral driving and rotating mechanism comprises an integral rotating mechanism (4) and an integral driving mechanism (8), the integral rotating mechanism (4) being connected to the rod (5) and connected to the integral driving mechanism (8) via a driving tendon, and the integral rotating mechanism (4) being driven by the integral driving mechanism (8) to drive the rod (5), the deformation section (6) and the distal effector (7) to rotate as a whole； the distal effector opening and closing driving mechanism (10) is connect to the distal effector (7) via a driving tendon to drive the distal effector (7) to open and close； and the deformation section (6) is connected to the corresponding deformation section deflection driving mechanism via a driving tendon, and the deformation section (6) is driven by the deformation section deflection driving mechanism to bend. The minimally invasive surgical instrument has the advantages of miniaturization and lightweight in operation driving, stable traveling of the internal driving tendons, highly concentrated driving integration due to the single-side driving arrangement, convenience for quick replacement during an operation, etc.L'invention concerne un instrument chirurgical minimalement invasif avec un agencement de plaque unilatérale d'entraînement. L'instrument chirurgical minimalement invasif comprend une partie d'entraînement proximale (1), un boîtier (2), une tige (5), une section de déformation (6) et un effecteur distal (7), la partie d'entraînement prox
