A pharmaceutical composition in the form of a tablet including a first portion and a second portion wherein said first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug resin complex. The second drug can be either an anti tussive or a decongestant. The drug resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin polacrilex resin polacrilin potassium cholestyramine resin or a colestyramine resin. The drug resin complex can be provided with a coating the coating thickness being selected to obtain the desired release profile. The drug resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%.
