Method for providing information for predicting the prognosis of radiation therapy comprising step of measuring the expression level of immune checkpoint of cancer cell which is changed during the radiation therapy and composition for radiation therapy
The present invention relates to a composition for the treatment of cancer in combination with a radiation treatment method including an information providing method for predicting the prognosis of radiation therapy of cancer by measuring the expression level of the immune gateway factor of cancer cells that changes during radiation therapy. According to the information providing method of the present invention, it is possible to predict whether the resistance to radiation treatment or the prognosis of radiation treatment is measured by measuring the expression level of the immune gateway factor of cancer cells that change during radiation treatment. In addition, according to the composition for the treatment of cancer of the present invention, the cancer can be effectively treated when used in combination with radiation treatment by controlling the activity of the immune checkpoint factor.본 발명은 방사선 치료 시 변화되는 암 세포의 면역관문인자 발현 수준 측정을 통해 암의 방사선 치료 예후를 예측하기 위한 정보제공방법, 면역관문인자 조절제를 포함하는 방사선 치료 병용 암 치료용 조성물에 관한 것이다. 본 발명의 정보제공방법에 의하면 방사선 치료 시 변화되는 암 세포의 면역관문인자 발현 수준를 측정하여 방사선 치료에 대한 저항성 여부 또는 방사선 치료 예후를 예측할 수 있다. 또한, 본 발명의 암 치료용 조성물에 의하면 상기 면역관문인자의 활성을 조절함으로써 방사선 치료와 병용하였을 때 효과적으로 암을 치료할 수 있다.
