Methods of treating hematologic cancers using pnp inhibitors such as forodesine in combination with alkylating agents or anti-cd20 agents

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专利权人:

BIOCRYST PHARMACEUTICALS INC.

发明人:

BANTIA SHANTA,BABU YARLAGADDA S.,BRETHFELD PHILIP

申请号：

NZ60107208

公开号：

NZ601072A

申请日:

2008.12.10

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

601072 Described herein is the use of (a) a PNP inhibitor (b) an anti-CD20 agent and optionally (c) an alkylating agent, in the manufacture of a medicament for treating a hematologic cancer in a subject in need thereof, wherein the medicament is formulated for separate, sequential or simultaneous administration of (a), (b) and (c). The combination of Forodesine, Bendamustine and Rituximab is exemplified. Examples of treated conditions include non-Hodgkin&rsquo；s lymphoma, chronic lymphocytic leukemia and acute lymphocytic leukemia.

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