INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/180857 Al 19 October 2017 (19.10.2017) WIPO I PCT 111111111111110111011111111111010111110 0111111011111H111111111111111111110111111 (51) International Patent Classification: A61K 48/00 (2006.01) C07K 14/755 (2006.01) C12N 15/86 (2006.01) (21) International Application Number: PCT/US2017/027396 (22) International Filing Date: 13 April 2017 (13.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/323,336 15 April 2016 (15.04.2016) US 62/331,807 4 May 2016 (04.05.2016) US 62/428,866 1 December 2016 (01.12.2016) US (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG
