SOULA, Olivier,SOULA, Gérard,DAUTY, Emmanuel,CHARVET, Richard
申请号：
ES13801658
公开号：
ES2670969T3
申请日:
2013.11.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Composition in aqueous solution, comprising insulin in hexamerican form, at least one substituted anionic compound and a non-polymeric polyanionic compound: - said substituted anionic compound chosen from the substituted anionic compounds, in an isolated or mixed state, constituted by a main chain formed by a discrete number or between 1 and 8 (1 <；= u <；= 8) of identical or different saccharide units, joined by identical or different glycosidic bonds, said saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, characterized in that they are substituted by: a) at least one substituent of general formula I: - [R1] to- [AA] m Formula I * the substituents being identical or different when there are at least two substituents, in which: * the radical - [AA] - designates an amino acid residue, * the radical -R1- being: - either a bond and then a>； = 0, and the rest of amino acid - [AA] is directly linked to the main chain by a G function. - or a carbon chain and then a>； = 1, from C2 to C15, possibly substituted and / or comprising at least one heteroatom chosen from O , N and S and at least one acid functional group before the reaction with the amino acid, said chain forming with the amino acid residue - [AA] an amide functional group, and is fixed on the main chain with the help of a functional group F resulting from a reaction between a hydroxyl functional group carried by the main chain and a functional group or a substituent carried by the radical precursor -R1-, * F is a functional group chosen from the ether, ester or carbamate functional groups, * G is a carbamate functional group, * m is equal to 1 or 2, * the degree of substitution of saccharide units, j, in - [R1] a- [AA] m being strictly greater than 0 and less than or equal a 6, 0 <；j <；= 6 b) and, eventually, one or more substitutes is -R'1, * the substituent -R'1 being a carbon chain from C2 to C15, optionally substituted and / or comprising a
