Germicidal irradiation push-button systems for disinfecting surface(s) of push-button(s). In an aspect, a germicidal irradiation push-button system comprises a push-button having a first surface recessed behind a panel, wherein the panel has an opening for accessing the first surface; an ultraviolet (UV) light source located behind the panel for irradiating the first surface; and a UV-light control module for controlling the UV-light source.