Spreading compounds, using methods and preparation methods that can inhibit or regulate the activity of tank combined with pentabromodiphenyl ether (tbk1).Quinasa i-kappa-b (ikke, IKBKE) is very useful in the treatment of cancer. 1. Claim 1: a formula compound (1),where: A is a 6-membered aryl or heteroaryl ring； X¹ is CR² or N； X² and X³ are, independently, CR³ or N, provided that, at most, only one of X² and X³ is N； R¹ is selected from the group consisting of H, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, -ORᵃ,-C (O) R-C (O) OR-C (o) No. 7491； (r7495)；-OC (O) NR R-No. 7491； No. 74955；-Cn, - No. 7491； - C (o) No. r7495；-No. 7491； (C (o) No. 74959；-S (O) R-S (O) NR R-No. 7491； (s (o) 8322； r74955；where each C₁₋₆ alkyl, C₂₋₆ alkenyl and C₂₋₆ alkynyl is optionally substituted with one to five R²⁰ groups；or R¹ has the structure of formula (2) where B is selected from the group consisting of C₆₋₁₀ aryl, C₃₋₁₀ cycloalkyl, 5-10 membered heteroaryl and 3-12 membered heterocyclyl； R² is selected from the group consisting of H, C₁₋₆ alkyl, C₃₋₁₀ cycloalkyl, 3-12 membered heterocyclyl, C₁₋₆ heteroalkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, -NRᵃRᵇ,Halogen, N, N, N, n-Or7491,-C (O) R-C (O) OR-C (o) No. 7491； (r7495)；-OC (O) NR R-7491； (C (o) r7495；-No. 7491； (C (o) No. 74959；-S (O) R-S (O) NR R y -NR S (O) Re. Each R 3 is independent of H, c8321；Halogen, N, N, N, n-Or7491,-C (O) R-C (O) OR-C (o) No. 7491； (r7495)；-OC (O) NR R-7491； (C (o) r7495；-No. 7491； (C (o) No. 74959；-S (O) R-S (O) NR R y -NR S (O) Reach R⁴ is independently selected from the group consisting of H, C₁₋₆ alkyl, C₁₋₆ heteroalkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, -NRᵃRᵇ,Halogen, C (o) r74919；-C (O) OR-C (o) No. 7491； (r7495)；-OC (O) NR R-7491； (C (o) r7495；-No. 7491； (C (o) No. 74959；-S (O) R-S (O) NR R-No. 7491； (s (o) 8322； r74955；-8323,-CN, -NO₂ and -ORᵃ；R⁵ is selected from the group consisting of H, C₁₋₆ alkyl, C₁₋₆ heteroalkyl, -NRᵃRᵇ,Halogen, C (o) r74919；-C (O) OR-C (o) No. 7491； (r7495)；
