James Kowalski;Arun P. Patal;Jay Parthiban Lakshman
发明人:
James Kowalski,Jay Parthiban Lakshman,Arun P. Patal
申请号：
US13562415
公开号：
US20120294939A1
申请日:
2012.07.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Dipeptidylpeptidase IV inhibitor (herein referred to as DPP-IV) that may be 98.5-100% pure is a high-dose drug capable of direct compressed with specific excipients into sold form dosage forms, such as tablets and capsules having desired, hardness, disintegrating ability and acceptable dissolution characteristics. DPP-IV is not inherently compressible and thus present formulation problems. Excipients used in the formulation enhance the flow and compaction properties of the drug and tableting mix. Optimal flow contributes to uniform die fill and weight control. The binder used ensures sufficient cohesive properties that allow DPP-IV to be compressed using the direct compression method. The tablets produced provide an acceptable in vitro dissolution profile.
