The present invention provides a syringe assembly for a medication pump, such as an insulin pump, or the like that includes a pair of protruding structures at one end that mate with the typical pair of opposed recesses or other notch structures of the syringe assembly mating portion of the pump, without the use of a cap structure and needle member, and that may be manufactured primarily from a relatively inexpensive plastic material or the like, while still providing the medication supply back-pressure required to be adequately sensed by the pump electronics, such that the pump accepts the syringe assembly and is “primed” for proper operation.