The purpose of the present invention is to provide a bone cement composition which can have desired biological activity performance and desired radiolucency while enabling the strength of a cured product thereof to be kept. A titanium oxide coating is formed on radiolucent particles to thereby produce composite particles, and the composite particles are added to a bone cement composition. The bone cement composition thus produced can be used suitably for the filling of a bone defect portion and the fixation of an artificial joint and in percutaneous vertebroplasty. The shape of each of the radiolucent particles is preferably granular, and the titanium oxide is preferably of a rutile type.本發明係以提供一種可維持硬化物之強度、且具有企求的活體活性能力及企求的X光造影性之骨水泥組成物為目的。在具有X光造影性之粒子中形成有氧化鈦被覆的複合粒子,且包含於骨水泥組成物中。該骨水泥組成物適合填充於骨欠缺部位、固定人工關節、使用於椎體形成術。具有X光造影性之粒子的形狀以粒狀較佳,氧化鈦以金紅石型較佳。
