Marco Emgenbroich,Johannes Josef Leonhard,Hans-Michael Wolff
申请号：
US15312542
公开号：
US20170079932A1
申请日:
2015.05.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Use of an additive in a transdermal therapeutic system with an active agent-containing layer in the form of a biphasic layer having a hydrophilic inner phase and a hydrophobic outer phase, wherein the inner phase comprises the additive and an active agent dissolved therein, wherein the additive has a higher affinity to water than to the active agent, for the control of the permeation rate of the active agent in a manner which is independent from its concentration in the biphasic layer, wherein the maintenance of the permeation rate is proportional to the amount of active agent in the biphasic layer.
