STAPLED AND STITCHED POLYPEPTIDES AND USES THEREOF

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专利权人:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人:

VERDINE, GREGORY, L.,HILINSKI, GERARD

申请号：

SG11201508431V

公开号：

SG11201508431VA

申请日:

2014.03.13

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

The present invention provides stapled polypeptides of the Formulae (I) and (VI): and salts thereof； wherein the groups ----- ； R 1a , R 1b , R 1c , R 2a , R 3a , R 2b , R 3b , R 4a , R 4b , RA, Rz, L 1a , L 1b , L 2 , L 3 , X AA , v, w, p, m, s, n, t, and q are as defined herein. The present invention further provides methods of preparing the inventive stapled polypeptides from unstapled polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of Formula (I) or (VI), and methods of using the stapled peptides. The present invention also provides modifications of the staples post ring closing metathesis.

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