The present invention provides a circuit applied to a biopotential acquisition system, wherein the circuit includes an active current source and an amplifier. In the operations of the circuit, the active current source is configured to provide a current to two input terminals of the circuit, wherein the two input terminals of the circuit are coupled to two input electrodes of the biopotential acquisition system; and the amplifier is configured to receive input signals from the two input terminals to generate an output signal.本申請提供一種應用於生物電勢採集系統的電路,其中,該電路包括主動電流源和放大器。在該電路的操作中,該主動電流源被配置為提供電流給該電路的兩個輸入端,其中,該電路的兩個輸入端耦接于該生物電勢採集系統的兩個輸入電極,以及,該放大器被配置為接收來自該兩個輸入電極的輸入信號,以產生輸出信號。